A 45-year-old male with a prosthetic aortic valve presented to the hospital with several months of generalized malaise.On admission, he was noted to have anemia of unclear etiology and subsequently became febrile with multiple blood cultures growing Lactococcus Panier Bike Seats garvieae.Inpatient workup was concerning for infectious endocarditis (
Misannotation of multiple-nucleotide variants risks misdiagnosis [version 2; peer review: 2 approved]
Multiple Nucleotide Variants (MNVs) are miscalled by the most widely utilised next generation sequencing analysis (NGS) pipelines, presenting the potential for missing diagnoses.These variants, which should be treated as a single insertion-deletion mutation event, are commonly called as separate single nucleotide variants.This can result in misanno
Ostreolysin A/Pleurotolysin B and Equinatoxins: Structure, Function and Pathophysiological Effects of These Pore-Forming Proteins
Acidic ostreolysin A/pleurotolysin B (OlyA/PlyB, formerly known as ostreolysin (Oly), and basic 20 kDa equinatoxins (EqTs) are cytolytic proteins isolated from the edible mushroom Pleurotus ostreatus and the sea anemone Actinia equina, respectively.Both toxins, although from different sources, share many similar biological activities: (i) colloid-o
Daratumumab plus lenalidomide and dexamethasone versus lenalidomide and dexamethasone in relapsed or refractory multiple myeloma: updated analysis of POLLUX
In the POLLUX study, daratumumab plus lenalidomide/dexamethasone significantly reduced risk of progression/death versus lenalidomide/dexamethasone alone in relapsed/refractory multiple myeloma.We provide one additional year of follow up and include the effect on Baby minimal residual disease and in clinically relevant subgroups.After 25.4 months of
A Study on Generating Webtoons Using Multilingual Text-to-Image Models
Text-to-image technology enables computers to create images from text by simulating the human process of forming mental images.GAN-based text-to-image technology involves extracting features from input text; subsequently, they are combined with noise and used as input to a GAN, which generates images similar to the original images via competition b